Symptoms and Treatment for Overose, and Antidote(s): None has been reported; Single oral doses of up to 160 mg and total oral doses of up to 300 mg/ day have been given without adverse effects.
Symptoms/Clinical Effects of overdose: The following effects have been selected on the basis of their potential clinical significance: Blurred vision; confusion; diaphoresis (increased sweating); drowsiness; dryness of mouth; flushing; headache; nausea; tachycardia (fast or irregular heartbeat).
Treatment: Since there is no specific antidote for overdose with omeprazole, treatment should be symptomatic and supportive. Due to extensive protein binding, omeprazole is not readily dialyzable. Patients in whom intentional overdose is confirmed or suspected should be referred for psychiatric consultation.